Phenytoin thrombocytopenia
WebApr 14, 2024 · Phenytoin is a commonly used anticonvulsant drug for the prophylaxis of generalized tonic-clonic seizures, partial seizures, and neurosurgery-related seizure prevention. Phenytoin-induced thrombocytopenia is a rare but life-threatening condition. WebOct 19, 2024 · Symptoms of a low platelet count can be bleeding gums and nosebleeds. Thrombocytopenia refers to an abnormally low level of platelets in the bloodstream. Platelets are important for normal blood clotting. With severe thrombocytopenia, excessive bleeding may occur. Thrombocytopenia occurs because there is decreased production or …
Phenytoin thrombocytopenia
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WebSep 2, 2024 · Phenytoin is used to prevent and control seizures (also called an anticonvulsant or antiepileptic drug). It works by reducing the spread of seizure activity in the brain. Phenytoin may also be used to treat certain types of irregular heartbeats. Phenytoin is available under the following different brand names: Dilantin, Dilantin 125, … WebMay 20, 2009 · Summary. Drug-induced immune thrombocytopenia (DITP) can be triggered by a wide range of medications. Although many cases of DITP are mild, some are …
WebThrombocytopenia is a platelet count of less than 150 × 10 3 per μL and can occur from decreased platelet production, increased destruction, splenic sequestration, or dilution or clumping.... WebMar 1, 1986 · Thrombocytopenia is a rare isolated complication of phenytoin therapy. The probable autoimmune etiology distinguishes this syndrome from other phenytoin- …
WebNov 3, 2005 · The authors then suggested that exposure to phenytoin after subarachnoid hemorrhage should be minimized and argued for a prospective study of phenytoin in patients at high risk for seizures after subarachnoid hemorrhage. ... but sodium valproate was suggested to be related to quantitative thrombocytopenia and functional defects in … WebFeb 24, 2024 · These have included thrombocytopenia, leukopenia, granulocytopenia, agranulocytosis, and pancytopenia with or without bone marrow suppression. ... Phenytoin Sodium Milpharm 100 mg film-coated tablets contain Sodium: Phenytoin sodium contains less than 1 mmol (23 mg) of sodium per tablet, that is to say it is essentially 'sodium-free.
Webleads to hypercoagulable state and thrombocytopenia. hypersensitivity. Pharmacology. IV delivery only for therapeutic anticoagulation. short half-life (2h) ... ASA, sulfonamides, and phenytoin. displace warfarin from plasma proteins, leading to increased free fraction → ↑ PT. cholestyramine. ↓ oral absorption. due to low pKa. Pharmacology ...
WebSep 2, 2024 · Phenytoin is used to prevent and control seizures (also called an anticonvulsant or antiepileptic drug). It works by reducing the spread of seizure activity in … health department germantown mdWebDec 1, 2024 · Phenytoin is extensively bound to plasma proteins and is prone to competitive displacement. Phenytoin is metabolized by hepatic cytochrome P450 enzymes CYP2C9 and CYP2C19 and is particularly … health department gallipolis ohioWebAs far as contraindications go, phenytoin should be avoided during pregnancy, as well as in clients with sinus bradycardia, heart block, and Adams-Stokes syndrome, which refers to a condition characterized by syncopal episodes caused by cardiac arrhythmias. health department gaylord miWebPhenytoin hypersensitivity can present with thrombocytopenia and leukopenia. Treatment with IVIG was associated with a rapid rise in the platelet count in the patient in this report. IVIG should be considered for patients with phenytoin-induced thrombocytopenia. Phenytoin-induced thrombocytopenia treated with intravenous immune globulin health department gladstone moWebNov 2, 2015 · In light of evidence that phenytoin reduces seizure risk in the first week after traumatic brain injury, 98 an American Academy of Neurology practice ... and radiation therapy in newly diagnosed glioblastoma patients may prolong survival at the expense of increased thrombocytopenia and leukopenia. 6, 103 A recent meta-analysis confirmed ... health department goldsboroWebOct 1, 2024 · Phenytoin clearance is decreased slightly in elderly patients and lower or less frequent dosing may be required [see Clinical Pharmacology (12.3)]. Dosing during Pregnancy. ... These have included thrombocytopenia, leukopenia, granulocytopenia, agranulocytosis, and pancytopenia with or without bone marrow suppression. ... health department goaWebJan 24, 2024 · Phenytoin is commonly prescribed for seizure prophylaxis in neurosurgical patients. However, phenytoin-induced serious adverse effect such as thrombocytopenia has been reported in the literature. gone i\u0027m gone hadestown lyrics