2024 Klf6 inhibitor

Klf6 inhibitor

Author: ykaj

August undefined, 2024

WebFeb 26, 2024 · However, KLF6 was identified as a tumor suppressor to inhibit glioblastoma by several research groups [34, 35]. Collectively, KLF6 may exert both anti-tumorigenic … WebApr 27, 2024 · KLF6 is a direct target of miR-24. a 3’UTR of KLF6 was highly conserved to bind with miR-24. b miR-24 mimic could repress the fluorescence in KLF6 wild type. c KLF6 expression was increased markedly in cardiac fibroblasts treated with LPS. d miR-24 mimic remarkably inhibited KLF6 expression. e KLF6 mimic could relieve the inhibition of PVT1 …

Krüppel-Like Factor 6 Splice Variant 1: An Oncogenic Transcription …

WebJul 1, 2005 · KLF6 is a member of the Kruppel-like family of zinc finger transcription factors which are DNA-binding proteins regulating growth-related signal transduction pathways, … WebRecently, Klf6 super-enhancer which strongly regulates Klf6 gene expression has been identified, and the function of Klf6 super-enhancer which regulates cell growth was … choi yuree

KLF6 - Wikipedia

WebDec 19, 2013 · KLF6 is ubiquitously expressed in human tissues and regulates many pathways such as differentiation, development, cellular proliferation, growth-related signal transduction, and apoptosis. ... KLF6 mRNA decreased within 45 min to 4 h in the presence of the transcription inhibitor actinomycin D and was reduced by 95% after 4 h of … WebMar 2, 2024 · The KLF6 gene, which belongs to the Krüppel-like family of C2H2 zinc finger TFs, is closely related to the formation, development, and metastasis of tumors in the malignant tumors, including prostate, colon, stomach, liver, lung, neck, pituitary and nervous system [ 15, 16 ]. WebView/Edit Human. View/Edit Mouse. Kinesin family member 6 is a protein that in humans is encoded by the KIF6 gene. [5] This gene encodes a member of the kinesin family of … gray romantic define

The Klf6-related super enhancer deletion by CRISPR/Cas9

KLF6 , a Candidate Tumor Suppressor Gene Mutated in Prostate ... - Science

WebAdenomatous polyposis coli (APC) also known as deleted in polyposis 2.5 (DP2.5) is a protein that in humans is encoded by the APC gene. The APC protein is a negative regulator that controls beta-catenin concentrations and interacts with E-cadherin, which are involved in cell adhesion.Mutations in the APC gene may result in colorectal cancer.. APC is … This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an importan… gray roll on bedlinerWebBackground: Macrophage polarization regulates human inflammatory disorders.Results: KLF6 is a novel transcriptional regulator of macrophage polarization.Conclusion: KLF6 regulates macrophage inflammatory gene expression by modulating functions of NF-κB and PPARγ.Significance: Pharmacological agents that modulate KLF6 signaling may allow for … gray rolls of tablecloth

"WebThe initial expansion of CD8 + effector T cells is followed by a contraction phase and concomitant development of CD8 + memory T cells [107].CD8 + memory T cells express IL-7 receptor (CD127) and IL-2 receptor β chain (CD122). The memory development is associated with the re-expression of CD62L and the up-regulation of CCR7, both of which … " - Klf6 inhibitor

Klf6 inhibitor

WebApr 4, 2024 · Hotspot mutant p53-R273H inhibits KLF6 expression to promote cell migration and tumor metastasis. KLF6 Induces Apoptosis in Human Lens Epithelial Cells Through … WebNational Center for Biotechnology Information

Did you know?

Web目的:检测诱导型一氧化氮合酶(inducible nitric oxide synthase,iNOS)在胃癌前病变及胃癌的表达,及其与幽门螺杆菌(Helicobacter pylori,Hp)感染的相关性,探讨Hp感染与胃癌发生的关系.方法:收集慢性浅表性胃炎(chronic superficial gastritis,CSG),慢性萎缩性胃炎伴肠上皮化生(Intestinal metapla WebMay 23, 2016 · (M-O) Confocal imaging analysis of Klf6-silenced and NT control mouse OLP pretreated with 2 μM caspase inhibitor Q-VD-OPh or vehicle for 2 h, then differentiated with T3 for 48 h. Apoptosis is almost absent from cultures exposed to the inhibitor, and Olig2 + cell numbers in Klf6-silenced and control conditions are almost identical (M,N).

WebNov 25, 2010 · Indeed, KLFs have been implicated in subtypes of leukemia, lymphoma, autoimmunity, and in acute and chronic inflammatory disease states, such as atherosclerosis, diabetes, and airway inflammation, raising the possibility that KLFs and their upstream signals are of therapeutic interest. WebAug 26, 2009 · Kruppel-like factor 6 (KLF6) is a tumour-suppressing protein. The aim of this study was to identify the role of KLF6 inhibition in estrogen receptor {alpha} (ERα)-elicited …

WebAug 9, 2024 · KLF6 binds to different acetyl-transferases, including cyclic adenosine monophosphate response element-binding protein ( CREBBP ), p300, and p300/CBP-associated factor [ 32 ]. The binding of KLF6 to these … WebThis review focuses on four widely investigated KLF members, KLF2, KLF4, KLF6, and KLF7, describing their molecular characteristics, physiological functions, regulatory factors, roles in cancer, and treatment. ... Smad7 is an inhibitor of TGF-β, which is a tumor-suppressor in the early stages of various cancers, including GC and CRC [98 ...

WebMar 21, 2024 · KLF6 (KLF Transcription Factor 6) is a Protein Coding gene. Diseases associated with KLF6 include Prostate Cancer and Gastric Cancer. Among its related …

WebJul 30, 2024 · KLF6 directly activates E-cadherin transcription to inhibit tumor invasion and metastasis 13. Besides, KLF6 also suppresses cell migration and tumor metastasis in an E-cadherin-independent manner. choize clean foodWebJun 1, 2004 · Abstract. Kruppel-like factor 6 (KLF6) is a tumor suppressor gene inactivated in prostate and colon cancers, as well as in astrocytic gliomas. Here, we establish that … gray rolling storage cartWebAug 22, 2024 · KLF6 expression increased axon extension, and combined VP16-STAT3/KLF6 expression significantly increased long distance axon growth above KLF6 alone. Arrowheads mark 1 mm intervals from the edge ... gray roll up shadesWebKrueppel-like factor 6 is a protein that in humans is encoded by the KLF6 gene. [5] It is a tumor suppressor gene. [6] Function [ edit] This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. gray rolling toolboxWebFeb 26, 2024 · Ectopic expression of KLF6 or disruption of CBX4-HDAC1 interaction attenuates CBX4-mediated cell growth and migration. Furthermore, CBX4 depletion markedly enhances the histone deacetylase inhibitor (HDACi)-induced cell apoptosis and suppression of tumor growth. Interpretation Our data suggest CBX4 as an oncogene with prognostic … choiz food storeWebDec 22, 2006 · KLF6 is ubiquitinated in vivo. 293T cells were transiently transfected with pcDNA-KLF6 and hemagglutinin-tagged ubiquitin (pHA-Ub) and cultured for 2 h with the proteasome inhibitor ALLN or vehicle alone (DMSO). Equal amounts of protein were immunoprecipitated with anti-HA-antibody and Western blotted with anti KLF6 or anti-Flag … gray romantic definitionWebApr 2, 2013 · KLF6 is a member of the Krüppel-like Factors (KLF) gene family which are a group of transcription factors that contain three highly conserved Cys 2 -His 2 type zinc fingers located in the C-terminus [ 1, 2 ]. Subsequently, these proteins regulate a vast range of target genes by preferentially binding to cognate GC-boxes or CACCC elements. gray roman shades