http://www.commonorganicchemistry.com/Common_Reagents/Boc_Anhydride/Boc_Anhydride.htm WebWith triethylamine In water; acetone at 20℃; for 4 h; ... In another flask BOC-anhydride was taken into 1,4-dioxane (25 ml), cooled to 0-5° C., added to the above reaction mixture and stirred the reaction mixture overnight. Extracted with ethylacetate (150 ml.x.1). The aqueous layer acidified with 1:1 aqueous. Hydrochloric acid up to pH 2 ...
Boc Protection Mechanism (Boc2O) - Common Organic …
WebBoc groups will survive the dilute HCl wash. TMS groups may not. Amine solvents (pyridine, di- and trialkylamines): Amines will partition into the organic layer during a typical aqueous workup. However, they become water soluble if you 1. Wash the organic layer several times with dilute HCl solution. The protonated amine will partition into the The Boc group can be added to the amine under aqueous conditions using di-tert-butyl dicarbonate in the presence of a base such as sodium bicarbonate. Protection of the amine can also be accomplished in acetonitrile solution using 4-dimethylaminopyridine (DMAP) as the base. Removal of the Boc in amino acids can be accomplished with strong acids such as trifluoroacetic acid neat or in dichloromethane or with HCl in methanol. A complication may be the tendency of the t … how to change your landline phone number
Triethylamine 121-44-8 - ChemicalBook
WebAcetonide 7 (139 mg, 0.41 mmol, 1.0 equiv.) was dissolved in dry DCM (10 mL), triethylamine (0.12 mL, 83 mg, 0.82 mmol, 2.0 equiv.) and Boc anhydride (179 mg, 0.82 mmol, 2.0 equiv.) were added and the mixture stirred overnight. WebTriethylamine (C2H5)3N or C6H15N CID 8471 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological ... WebJan 24, 2012 · Amines are converted to N-tert- Boc derivatives by reaction with di- tert- butyldicarbonate (Boc) 2 O in the presence of: 4- (dimethylamino)-1- tert -butylcarbonylpyridinium DMAP [ 10 ], 4- (dimethylamino)-1- tert -butylcarbonyl pyridinium chloride [ 11] or tetrafluoroborate in aq NaOH [ 12 ], tert -butyl-2-pyridyl carbonate in the … michael w baker